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Intensely Diffuse Pattern Alopecia- Treatment & Solutions

Intensely Diffuse Pattern Alopecia- Treatment & Solutions

Treatment & Solutions for Intensely Diffuse Pattern Alopecia in Women/Female

Introduction to Female Pattern Hair Loss

Female Pattern Hair Loss (FPHL) is a specific type of hair loss pattern that is more common among women. In most cases, it happens between 30 to 50 years and causes negative psychological effects on the patients. Today, more than 40% of women are prone to FPHL. Only a few, i.e. less than 45% of women touch 80, with head full of hairs.

Those suffering from FPHL witness gradual shedding or reduction in hair volumes. At times, it happens simultaneously. There are different causes behind this distinctive hair loss pattern.

Some women have FPHL-causing genes, responsible for thinning scalp hairs. As for others, certain disorders in the androgen levels in their bloodstream might also lead to female androgenic/ diffused alopecia (other terms of FPHL). Some other reasons include molecular growth factors, environmental concerns, hormone disorders, and inflammatory mechanisms.
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Characteristics of Female Diffuse Alopecia

The most common reason of female baldness is characterised by centripetal hair loss. In such condition, the hair follicles miniaturise. As a result, hairs thin down, while preserving the hairline. Contrary to male pattern baldness where patients lose all their hairs, women only lose maximum hairs, not all. They witness the following characteristics:

  • It is a common phenomenon in the anagen (growth phase) and telogen (resting phase)
  • More than 80% of FPHL is a genetic issue
  • Front hairline remains unaffected. Women have central type alopecia
  • Matured hairs convert to fine downy hairs, causing hair miniaturization
  • Excess hair thinning, from 0.06mm to about 0.03mm and even less
  • Hair fall pattern follows the path of perifollicular inflammatory infiltration
  • Increased production of fibrous stele and fibro-vascular serpentines
  • Apoptosis regulation alters, thus causing self-destruction of cells
  • In about 50% of women suffering from this hair loss pattern, hyper-androgynism is not associated


Treatment for Female Diffuse Alopecia

Although the pathogen causing the hair loss has not been discovered yet, however, certain pathological and lab experiments have found its effective response to local and pharmacological treatments. And all such experiments have lead to a treatment procedure called differential diagnosis.

Female hair loss can happen from various reasons. These include fever, anxiety, pregnancy, thyroid diseases, cicatricial alopecia, telogen effluvium, polycystic ovary syndrome, alopecia from Vitamin-D or Iron deficiency, traction alopecia and diffuse alopecia areata.

In order to determine the actual cause of the hair loss pattern, surgeons conduct blood rest and study the nutritional, hormonal and immunological factors. Based on their understanding, they get into the roots of the problem and devise the most appropriate treatment for the disorder.


Combination Treatment for Intense Diffuse Alopecia

Intense diffuse alopecia in women is treated through a combination of 4 medical therapies- Low Level Laser Therapy (LLLT), Platelet-Rich Plasma (PRP), Carboxytherapy and Mesotherapy.
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  1. Low Level Laser Therapy (LLLT)

LLLT is a non-invasive treatment in which light emits from a device and enters deep into the scalp. In this process, dermatologists use helium-neon (632.8nm), or excimer (308nm), or fractional erbium-glass (1550nm) lasers to release red light into the targeted scalp region.

Photons from the emitted light mix with cytochrome C oxidase and produces adenosine triphosphate (ATP).  ATP, so formed, helps to increase blood flow in the scalp and metabolises the catagen and the telogen hair follicles. This leads to the production of new anagen hairs. In this therapy, nitric oxide released from cells distributes oxygen and vital nutrients to the roots of hairs. LLLT treatment also prevents excess build-up of dihydrotestosterone (DHT), a component responsible for androgenic alopecia in women.


  1. Platelet-Rich Plasma (PRP)

In this procedure, the dermatologists take the patient’s blood and finely process it. Them they extract the platelet-rich plasma cells and inject them into the scalp. Essential proteins and nutrients of the cells influence natural hair growth. It enhances the rate of metabolism of the cells, increases the production of collagen, and activates stem cells. All such factors activate the hair follicles, which further leads to potential hair growth.

PRP treatment has several benefits. It is simple and non-surgical procedure. Thus, patients hardly go through any kind of discomfort. It provides safe, reliable and natural looking results. Candidates have quick recovery, after this treatment. It is also cost-efficient and takes minimum time for the entire process. Based on modern technology, its a convenient and flexible therapy.


  1. Carboxytherapy

Carboxytherapy refers to the injection of carbon dioxide (CO2) into the targeted scalp area, which helps in promoting the flow of blood. Due to the mechanism, it stimulates the hair follicles and restores hair on the scalp. Carboxytherapy is often combined with LLLT, for more effective results. Surgeons use surgical steel needles to insert CO2 gas into the scalp. While doing so, they form an abrasion and activate the platelets.

In the combined treatment program, Carboxytherapy is alternatively performed with PRP and Mesotherapy. As the treatment advances, it gradually shows result. However, it is very painful treatment for patients. Since scalps are highly sensitive to pain, it develops pain. To restrict the painful effects, the surgeons apply analgesic, about 30 to 40 minutes prior to the treatment. Once the procedure comes to an end, patients undergo minimal feelings of pain.


  1. Mesotherapy

Another amazing hair loss treatment, Mesotherapy, along with PRP and Carboxytherapy provide wonderful results. In Mesotherapy, dermatologists or surgeons provide a boost of vitamin to the scalp. As a result, blood circulation within the specific area improves, and hair follicles are well nourished. Such factors stimulate hair re-growth and bring back lost hair, with immediate effect.

The Mesotherapy solution also works on the dihydrotestosterone (DTH) hormone and neutralizes its effects. During the procedure, surgeons consider the hair loss intensity and tenure of treatment to make micro-punctures on the scalp. On an average, the density of punctures is 0.2ml. This process continues till the end of treatment.


Distribution of Treatment Sessions for Intense Diffuse Alopecia

Usually, combined therapy for treating intense diffuse alopecia comprises of 10 LLLT, 3 PRP, 4 Carboxytherapy and 4 Mesotherapy. It is a 11-week treatment. While LLLT is consistently used for all the sessions of the treatment, the others are alternatively used along with LLLT.

Here is the treatment session breakup:

Week Session 1 Session 2
2 Meso LLLT
3 Carbo LLLT
5 Meso LLLT
6 Carbo LLLT
7 Meso LLLT
9 Carbo LLLT
10 Meso LLLT
11 Carbo LLLT


Results of Combined Intense Diffuse Alopecia Treatment

After undergoing a combined intense diffuse alopecia treatment, candidates gradually witness reduced hair loss rate. They have high hair density and greater vitality in their capillaries. Hair calibre also increases, however it becomes noticeable only after 6 months of treatment.



To sum up, FPHL is becoming a growing concern among women. However, combined therapy enables them to overcome such challenges and grow natural hairs, mostly through non-invasive ways. It produces more effective and good quality results, over the time. Since it is a medical procedure, candidates must look for trained and qualified surgeons or dermatologists having hands-on experience in this field. Wrong choice can often lead to bad consequences. Thus, people must be very careful and approach the right doctor or clinic for the treatment.
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