Dr. Sandeep Bhasin (Sr. Cosmetic Surgeon) is also an expert in alternative medicine & is offering Alzheimer’s cure/treatment in Delhi. Alternative medicine & combination of therapies has shown positive results in treating patient suffering from Alzheimer’s disease worldwide & that too without any sideeffects. This includes Ozone Therapy, Coconut Oil & more…
Alzheimer’s disease is the most common form of dementia which causes steady loss of memory, cognition disorder, and mental decline. The condition gets worsen over time, but at what speed this happens differs. With the development of Alzheimer’s dementia, some people lose the ability to do routine tasks in the initial few years while others may do fairly well until much later in the Alzheimer’s.
Slight memory loss is normal in some people above ages of 65-70 years. It may not mean that you have AD. But if your memory is getting worse, talk to your GP. If it is Alzheimer’s, timely treatment may help.
Symptoms of Alzheimer’s differ from individual to individual and it is always better to get tested than neglect the signs as Alzheimer’s disease only progresses with time.
Healthcare experts are Researching on “BIOMARKERS” (biological signs of disease found in blood, brain images and cerebrospinal fluid) to study if they can find early alterations in the brains of cognitively normal people and people with MCI who may be at higher risk for Alzheimer’s. Research suggests that such early detections may be possible, but more research is required before these methods can be completely relied upon to diagnose Alzheimer’s in regular medical practice.
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Myth #1: Alzheimer’s disease and Dementia is the similar thing.
Fact: Dementia in itself is not a particular disease; rather, the term denotes a group of symptoms that can be caused by different brain disorders. Dementia is featured by deficit intellectual functioning like memory loss, language problem, flawed reasoning and judgment while Alzheimer’s is just one of many kinds of dementia though it is the most common one.
Myth #2: Alzheimer’s disease only occurs in old age people
Fact: While people diagnosed (Diagnosis of Alzheimer’s Disease) with AD are usually above age 65, however an estimated of 200,000 Americans each year below 65 years of age are diagnosed with early-onset (also known as younger-onset Alzheimer’s).
Myth #3: Alzheimer’s symptoms are ordinarily a part of aging and not a disease
Fact: Some memory loss tends to take place as we age, but memory loss is not mandatory with increasing age and also memory loss related to Alzheimer’s disease interrupts a person’s routine life, steadily taking away his/her ability to learn, act and perform daily tasks. This kind of memory problem does not happen in age related loss.
Myth #4: Alzheimer’s is not lethal to pose threat to one’s existence
Fact: Alzheimer’s is actually the 6th leading cause of death in United States. Additionally, the chance of fatal accidents also increases with high-risk behaviors in moderate stages of AD.
Myth #5: There are many successful treatments available for Alzheimer’s disease
Fact: Alzheimer’s is presently the only illness in US out of 10 deadly diseases that cannot be prevented, cured, or reversed. Apart from drug inhibitors, supplements like vitamin E have also shown to be ineffective in treating Alzheimer’s symptoms.
Myth #6: Aluminum made items cause Alzheimer’s disease
Fact: This is a false notion that emerged out from some studies that showed higher levels of aluminum in the brains of people with Alzheimer’s, however; some studies did not support this.
Myth #7: Aspartame causes Alzheimer’s disease
Fact: There is no proof that the artificial sweetener aspartame such as Nutrasweet and Equal causes Alzheimer’s disease or even memory loss.
Myth #8: Flu shots elevates the risk of Alzheimer’s disease
Fact: Flu shots are certainly not the victim for Alzheimer’s development. In fact, several studies have shown that flu shots and some vaccinations helped to reduce the risk of Alzheimer’s.
Myth #9: If your parent had Alzheimer’s, you will have it too
Fact: Sadly, studies have also demonstrated that people with a first-degree relative (parent, sibling, or child) with the Alzheimer’s disease are at a greater risk of developing it by themselves. A deterministic gene is the one that straight away causes a disease, assuring that anyone with the gene will inherit the disease, like the one that causes early-onset Alzheimer’s. Risk genes on the other end are those that increase the chances of developing a disease, but it is not guaranteed. APOE-e4 is one such risk gene that is there in about 20-25 % of Alzheimer’s cases.
Myth #10: Head injuries cause Alzheimer’s disease
Fact: Not everyone who comes into contact of severe head injury will develop Alzheimer or dementia. However repeated mild head traumas traumatic, like mild concussions from contact could be associate to a kind of dementia known as chronic traumatic encephalopathy (CTE).
Before the actual successful treatment in pipeline for Alzheimer’s and other neurodegenerative diseases, we would like to show you the current treatment plans available, which have side effects and even after spending over a billion in research and clinical trials with conventional medicines, researchers are not getting success.
Namenda (memantine hydrochloride) is an orally active NMDA inhibitor used for the treatment of moderate to severe Alzheimer’s disease. This orally active NMDA inhibitor antagonist is thought to be the most effective treatment to slow down the advancement of Alzheimer’s and other types of dementia in its later stages. But the drug is not fully safe and brings along various side effects.
Memantine hydrochloride is an Alzheimer’s disease treatment and functions by impeding the chemical messenger glutamate. Glutamate is released in the brain in abundance when brain cells get damaged by the Alzheimer’s disease and this worsens the situation even more. Memantine is a clinical drug antagonist that is used to protect the brain cells by obstructing the adversities of excessive glutamate. It is permitted to treat severe Alzheimer’s, but can also be prescribed for moderate cases.
However, there is a significant risk element linked to Namenda consumption. Namenda (memantine hydrochloride) may interact with cough medicine consisting diuretics (water pills), dextromethorphan, oral diabetes medicine containing metformin, treatment medication for glaucoma, nicotine, cimetidine, sodium bicarbonate, ranitidine, quinidine, and some antiviral medicines.
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Before taking Namenda as a treatment for Alzheimer’s, it is quite essential to mention your physician about all the over-the-counter medications you take and all prescription. Namenda (memantine hydrochloride) must only be used when prescribed by an expert clinician during pregnancy period. It is still not confirmed if this drug passes into breast milk. Talk to your doctor before breastfeeding.
The authoritative Centre for Namenda (memantine hydrochloride) has already given a broader view of available of the potential side effects when taking this Namenda (memantine hydrochloride) medication for Alzheimer’s cure.
Stop using Namenda (memantine hydrochloride) and consult your doctor immediately as and when you see these serious side effects.
Solanezumab drug is an antibody that is mainly used to wipe off of the amyloid proteins from the blood stream and cerebrospinal fluid. Build-up of amyloid plaques is known to be the major cause of damaging cerebral system and brain tissues that further leads to cognitive impairment and mental functioning. The abnormal proteins can carryon to build-up plaques in the brain. Eli Lilly, the company that manufactures solanezumab, made a public statement on 23 November last year that it would quit the drug as a treatment for people with mild dementia. The result even adds to a long index of other promising Alzheimer’s drugs that have collapsed in the clinic, many of which, such as solanezumab, objected amyloid.
“Solanezumab” is a drug that was identified as a crucial test of the principal theory behind the Alzheimer’s disease. But the drug was unable to pass the huge trial of patients with mild dementia. Critics of the ‘amyloid hypothesis’, which asserts that the Alzheimer’s disease is prompted by the build-up of a protein in the brain called as –amyloid protein, have captured on the ultimate results as a witness of its incompetency. But the healthcare board is still unable to find solid evidence if this drug theory will eventually yield a treatment.
Proponents of the theory have extremely disappointed in a specific way for people at risk of the Alzheimer’s, or even in people with the disease in which solanezumab, the drug involved in the clinical trial, have led to the failure.
The Eli Lilly clinical trial, referred to as EXPEDITION3, engaged more than 2,100 people diagnosed with mild dementia caused due to Alzheimer’s disease. Out of the total of all, half were given monthly infusions of solanezumab and the other half received the placebo. The two groups were put under observation for 18 months and tested in a gamut of cognitive tasks. Examination of patients with comparable symptoms in previous studies of solanezumab had appeared stimulating, but the latest trial conducted by the company suggested only minor advantages, not sufficient to warrant usage of the drug.
The study for drug-solanezumab not only let down the millions of patients marking time for a successful disease-altering treatment for Alzheimer’s disease,” but also fall off for the primary purpose of mopping the plaque build-up from the brain for which it was made.
Ultimate Results from the final, large stage clinical trial, referred as “Expedition3,” produced that people with mild Alzheimer’s disease who were given solanezumab did not respond any better than patients who took placebo on tests of mental function and memory. It was in fact carried out that the protein (beta amyloid) which was meant to wash off from the brain turned toxic when it structured into clumps in between the brain’s synapses. The testing drug-solanezumab has not proved fruitful to diminish the formation of amyloid ‘plaques’, in people with Alzheimer’s or at risk of developing it.
It is the next big and thought to be one of the promising drugs in the clinic manufactured by Biogen, which has stirred some considerable expectations for treatment therapy of Alzheimer’s disease. Unfortunately the drug comes with a panicking safety history.
Biogen, a pharmaceutical company based out of Cambridge, Massachusetts, is testing a kind of antibody known as aducanumab, which aims to latch out and isolate amyloid plaques in the brain. In a clinical testing, the aducanumab antibody depicted weak signs of washing amyloid and reducing the issue of memory decline in patients with mild Alzheimer’s. The Biogen belonging- aducanumab shows some side effects of faster heart rate, chest tightness and sudden headaches.
Other chronic illnesses like cardiovascular disease, cancer, and HIV, have been improved through the use of combination therapies of Metabolic Therapy and Ozone therapy and now research has been carried out to treat Alzheimer’s Disease with a success.
Combination therapy is a success in Alzheimer’s disease because it is a complex disease. Let me explain with an example…
This protocol is a combination of Metabolic Therapy in combination with Ozone therapy. With this protocol, patient will get positive results in 2-3 months.
Ray of Hope! Alzheimer’s disease can be treated. In early cases we can reverse the disease and in severe cases, neurodegenerative disease can be stop from progressing. Not only Alzheimer’s disease but can also treat the following diseases:
Scientifically, ozone is oxygen with an extra molecule added and higher level of energy. It is fluctuating and quickly reactive.
Ozone is not a drug and it is not a magic bullet. It is a therapeutic tool of great power which can aid the body in regaining health. However, in the end, it is the immune system that has to do the work of healing the body. Therefore, the immune system must be functioning.
In a living organism, the immune system is typically controlled by the midbrain, the limbic mechanism, through the thymus. The limbic system is also objected to control the emotions. If the emotions are interrupted, the immune system is restrained or shut down.
Ozone for this matter obstructs tumor subsistence. Furthermore, ozone combusts the outer lipid layer of poisonous cells and kills them through cell lysis also termed as break-down. Phagocytes generate hydroxyl and hydrogen-Peroxid to kill viruses and bacteria. The production of hydroxyl by killer cells is detracting to their cytotoxic capacity. Ozone encourages conversion of nitrate and nitrite by phagocytes, L- arginine to citrulline, inducing on tumors. The aim of ozone therapy is to make atmospheric oxygen come in close connection with the hemoglobin of the blood and allow the exchange of oxygen with CO2, thus eradicating this end product of oxidation along with other products in precise quantities. In the respiration process, waste products are revealed to the action of oxygen and they are burnt, producing body heat.
Ozone process for Alzheimer’s disease treatment disrupts the integrity of poisonous bacteria’s, viruses, fungus, yeast, and protozoa. Ozone therapy typically includes the process of –
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Brain Health and overall Health is entirely upon a pure, healthy blood circulation and general humoral transfusion. The health of the brain, every organ, tissue, cells and nerve is dependent upon vital blood transfusion for optimal skull nourishment and degradation of wastes. When these vital fluids are flawed, the system starts a basis degeneration deterioration of the cognitive abilities from the norm.
The aim and function of ozone therapy for the treatment of Alzheimer ’s disease, Parkinson’s Disease and Multiple Sclerosis, etc. rests upon the mechanism of –
As per a latest study conducted by the French and Russian doctors, it is obtained that a cause of development of Alzheimer’s diseases is aluminum toxicities in the brain, and oxidation of the blood has been depicted to precipitate the aluminum content. This Recent study has shown immensely breathtaking results in the treatment of Alzheimer’s disease with ozone therapy.
Also, of course, its competencies as a cell rejuvenator and circulatory stimulator come into play. In a similar perspective, German doctors have also succeeded with Parkinson’s disease, MS and other neurological disorders.
It is being carried out that almost all kinds of nervous, blood, respiratory and functional, disorders can be successfully treated by ozone therapy. The impacts of oxidation are perfectly natural; the brain nerves being left toned and relaxed with a feeling of elasticity and galvanization.
The oxidation therapy encourages the vasomotor system by way of nerve centers, which fact is clearly seen in the increased sensation of warmth in the entire body and redness of the skin, and waste products being more freely removed. The ozone treatment clearly demonstrates that poor oxidation in the brain and nervous system is the cause of many cerebral disorders, by reason of the actuality that when the temperature is brought back to normal, the problems vanishes.
A rise in oxidative damage markers, which includes oxidation of proteins, DNA, RNA and lipids, clearly shows the development of Alzheimer’s and other neurodegenerative diseases and thus result in progressive brain damage. Oxidative stress also plays a critical role in the pathophysiology of neurodegenerative diseases like: Alzheimer’s dementia disease, Parkinson’s disease, Huntington and amyotrophic lateral sclerosis disorders.
Alzheimer’s dementia disease is a disorder of improper collection of proteins (amyloid plaques, Lewy bodies), fibrillary tangles and plates, including genetic mutations, inflammation, mitochondrial dysfunction, activation of glial, and oxidative stress, which ultimately lead to the progressive depreciation, putting patients with neurodegenerative diseases.
Ozone therapy in form of Redox (Oxidation-reduction) process play a crucial role in release of hormones, existence of cells in nervous system during embryonic stages, cell physiology, involvement in cellular signaling, cellular plastic phenomena, cell migration, and sphere from renewal of membranes, mitosis, cell synthesis, structure of second messengers and expansion in transcription of cytokines during inflammatory processes.
Oxidatívo stress leads to reactive compounds extracted from the lipoperoxides, like 4-hidroxinonenal (4-HNE) and malondialdehyde (MDA) which persuade an array of alterations in proteins Evidence of oxidative stress in brain of patients extracts from studies that show increase in protein carbonyls, lipid peroxidation and oxidation of mitochondrial DNA. The evidence of oxidative stress in Alzheimer’s disease rests upon the following aspects:
These findings may explain the rationale like this
So, many of you may be wondering about what it actually mean to have a ketogenic brain? In this section we will provide you an evaluation of brain energy and neurotransmitters more closely, particularly, glutamate and GABA.
GABA is believed to be a prominent blockage neurotransmitter in the mammalian nervous system. Comes out, GABA is produced from glutamate, which occurs to be the dominant excitatory neurotransmitter. You literally require the two of them, but any excess of the both could certainly put you in danger. Too much activity and commotion in the brain suggests neurotoxicity, the severe indication of which is seizures. But neurological disorders as distinguised as Alzemier’s, forms of dementia, bipolar disorders, depression and migraines have all been associated to neurotoxicity in some way or the other.
Glutamate has an assortment of consequences, rather like our old companion- tryptophan. It can become aspartate (in excess, neurotoxic, excitatory) or GABA (blockage).
Ketogenic diets appear to co-operate glutamate in becoming GABA instead of aspartate. The exact reason is unknown, but a module of the reason is certainly linked with how ketones are metabolized, and how ketosis cooperate using acetate (acetoacetate is after all one of the ketone bodies itself) for fuel. Acetate becomes glutamine, a crucial forerunner for GABA.
A premium ketogenic diet for the cure and prevention of Alzheimer’s and other neurodegenerative diseases had 3 main components which were assumed to submit to the anti-seizure effect. These includes-
Well, the catch is -in the brain, it is everything about energy. The brain requires a tremendous amount of energy to keep all the cell membrane potentials well balanced and maintained, to keep pushing out sodium from the cells and draggin potassium into the cells. In fact, the brain, which is just 2% of our total body weight, consumes 10% of our glucose and 20% of our oxygen reserves only to keep operating. (Some of our brain cells are really too minute or have tendrils that are too tiny) to lodge mitochondria (the power plants). In such places, we should use glucose itself through glycolysis to form ATP. When we replace the prime fuel of the brain from glucose to ketones, we modify amino acid management too. And that indicates we altered the proportions of glutamate and GABA. The ideal responders to a ketogenic diet for epilepsy finishes up with the largest amount of GABA in the central nervous system.
Putting it across like this would be much easier to make everyone understand the essence of ketogenic diet in the enhancement of nervous system. As already a known fact that, Breast milk has an enormously high fat content. Newborns majorly spend time in ketosis, and are hence to some degree keto-corrected. Breast milk also has a high fat sugar value, but child’s brains are so capacitive they can tackle a whole lot more sugar than the fully developed adults. By keto-corrected we mean that little tots can more effortlessly become ketone bodies into myelin and into acetyl-coA. Ketosis aids the little babies’ structure and develops their brains. Infants are basically in mild ketosis, but very young babies purport to channelize lactate as a fuel as a substitute of glucose also, and the use of lactate also encourages the same utilization of acetyl-CoA and provides the neonates some of the benefits of ketoadaptation avoiding being in state of heavy ketosis.
Besides its reputation as a bodybuilding tool, many people take glutamine to enhance brain function because it fuels two of the brain’s most important neurotransmitters: glutamic acid and gamma-aminobutyric acid (GABA). Because glutamine provides energy for the brain, natural healing practitioners often recommend glutamine supplements and glutamine-rich foods to reduce cravings for detrimental brain stimulants such as sugar and alcohol.
A glutamine-revved brain supposedly becomes more alert, sharp-witted and also more erotically inclined; some practitioners prescribe glutamine for sexual dysfunction. Glutamine enthusiasts say it helps remove toxic metabolic residue from the brain, which further improves neural function. But others caution that in some people, a serious excess of glutamine could overexcite or even damage brain cells
Fatty acids, which comprises of Omega-3 and Omega-6 type fatty acids, are an essential element of cognitive processing. They also play a key role for a large group of different things in the body, such as preventing cardiac arrests and dysfunction. These Omega Fatty Acids are a component of a group called as essential fatty acids.
This suggests that your body is incompetent to produce them on its own as humans falls short of the desaturase enzymes needed for their production. They should either be consumed by direct supplementation or dietary intake. This is the moment when the ketogenic diet comes in – a diet loaded with essential fatty acids.
Data has revealed that a proper “Westernized diet” is scanty in essential fatty acids, much particularly in Omega-3s. Not only does fatty acids contains the majority of brain tissue, they are equally significant in the brain’s function, having a direct connection to memory, learning, and sensory performance.
Many Research studies have revealed the requirement to not only embrace your diet with essential fatty acids, but create and sustain a rational ratio of Omega-3s to Omega-6s which should be somewhere around a ratio between 1:1 and 1:4 Omega-3s to 6s. This is most viable on the ketogenic diet as we consume adequate of healthy oils (such as olive oil, coconut oil) that help maintain this ratio.
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Although conventional genesis still misunderstand that “the brain requires glucose” for “the brain can only function on glucose,” given enough adaptation, the brain can extract about 75% of its nutriment from ketone bodies, which the liver structures using fatty acids. If we could only utilize glucose, we would fail to make it stretched just a few days without food.
If our brains are unable to use fat-extracted ketones, we would fall dead as early as our liver had worn out its ability to churn out glucose. We would just get decompose, our lean tissue soluble into amino acids for hepatic metamorphosis into glucose to feed and fuel our insatiable brains.
A ketone diet is most popular for being a low carb diet, where the body builds-up ketones in the liver to be utilized as an alternative energy for the source of glucose. It is called by various terms such as – ketogenic diet, low carb high fat (LCHF), and low carb diet etc. When you feed yourself with something high in carbs, your body will automatically produce glucose and insulin.
The sufficient-protein, low-carbohydrate, high-fat ketogenic diet is used in medicine chiefly to treat complex-to-control (refractory) epilepsy in children. The dietary mean stimulates the body to burn more fats instead of carbohydrates.
With Alzheimer’s disease, it becomes troublesome for the brain cells to metabolize glucose, the brain’s chief source of energy. Ketones skip out on this fault in glucose energy metabolism. If adequate ketones are available on an ongoing basis, they could meet almost all of brain’s energy demands. However, ketones are only made when there is considerably low consumption of carbohydrate; this usually occurs when little no food is being fed, like when fasting.
Brain cells operate with far more proficiency and efficiency when they are using the ketone fats as a fuel resource as opposed to sugar. The overwhelming revelation is that the research scientists are now taking great dominance of this finding in the real treatment of Alzheimer’s dementia disease.
Ketones have appeared to audibly substantiate the brain health benefits of a high-fat/ low-carb, diet and also as a powerful transition to a healthy lifestyle to achieve the aim of improved brain health, functionality and cognitive improvement and strengthening. While there literally exists science based pharmaceutical “medical foods” for satisfying the brain needs of Ketones, you can increase the supply and availability of ketones for your brain by just adding coconut oil or MCT oil to your routine life. But to make this incredibly effective, carb confinement is a must!
Alzheimer’s dementia disease as a matter of fact now affects some 5.4 million people all across the globe. The belief of many mainstream researchers and healthcare experts is that this dietary approach may go a long way to sustain a healthy brain and allowing people to liberalize from this lethal disease.
Health Researchers have studied to animal models to appropriately understand how ketosis might guard the human brain from neuro-degeneration. In a mouse model of Alzheimer’s disease, level of beta-amyloid, a harmful protein that is eloquent in Alzheimer’s, were depleted in the brains of mice eaten a low-carb/high-fat diet compared to those on a regular diet. The latest study findings aided to clarify the connection between the metabolic advantages of ketones, improved cognitive function and reduced toxic lower amyloid.
This study tested the impacts ketones both in neurons treated with amyloid and a mouse model of Alzheimer’s disease. While amyloid elevated oxidation and obstructed exercise of a mitochondrial enzyme complex, ketones reversed these effects, validating their neural metabolic advantages. In addition, ketones decreased the level of toxic amyloid and impeded the construction of pores in cell membranes persuaded by amyloid, suggesting that ketones can safeguard against neuronal damage associated to amyloid. It is also helpful to restore normal synaptic plasticity that was destroyed by the amyloids. And lastly, ketones regained normal memory mechanism that was impaired by the harmful amyloids build-up.
Despite years of research and hard work to create a drug that cures or prevents Alzheimer’s disease (AD), the most common form of dementia targeting our aging population, there is presently no 100% successful treatments for this dreadful disease.
However, emerging research shows that such a WONDER treatment might already exist, not in the form of a drug, but simply as a dietary modification. An increasing number of research reports suggest that arbitration to enhance metabolic health can reduce symptoms and alleviate brain pathology associated with Alzheimer’s disease.
Alzheimer’s has multiple causes, but their common thread for risk factors may include health ailments, such as diabetes, high cholesterol, and inflammation.
Just like our muscles, the brain also needs energy to process appropriately. Both muscles and neurons have the individualistic potential to metabolize ketones as an alternative fuel source when there is shortage of glucose, for example when on a low-carbohydrate diet or fasting. The scientists in 1920s found out that a high fat diet encouraging ketogenesis controlled epilepsy, and ketosis persist to be one of the most potential treatments for Alzheimer’s. This also led to emergence of the likeliness that ketones may also be neuro-protective against other diseases that originate from abnormal neural metabolism, like Alzheimer’s disease. Since then, study reports have validated that ketones do in fact modify brain metabolism in a manner that diminish neuropathology and mitigate behavioral symptoms.
Underlying the amassing of excess body fat is something far stealthier: the gradual retrogression and abrupt processing of the brain, which leads to the Alzheimer’s disease and other types of dementia stages of memory loss, MCI.
Due to the reason of glucose and insulin processing in the brain are so flawed by the time one introduces into the dementia stages, a ketogenic diet would be a potential natural cure for Alzheimer’s disease as it can decelerate or even reverse the symptoms. Owing to the reason, as the brain is now burning ketones for energy in place of glucose, which can aid to restore function.
Over the past decade, various analysis reports have favored the clinical worth of ketosis in cognitively impaired patients. In a research study held in 2004, 20 patients with Alzheimer’s disease (AD) or Mild Cognitive Impairment (MCI) were treated with placebo or medium chain triglycerides, a kind of saturated fat in coconut and palm oils that stimulates ketone formation. The treatment elevated level of ketones after 1.5 hours, and these increased ketone levels harmonized with superlative memory improvements.
This initial, short-term derivation was then followed up 5 years later in a broader and longer-term study of 152 mild AD patients. 45 days later, patients taking a ketogenic compound produced cognitive improvements comparative to a placebo group.
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